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Scientists engineer proteins that can now make obese mice to exponentially lose weight and lower their cholesterol. This is somewhat crucial now that almost 40% of Americans are now considered obese; can these findings create a pill for humans that can have the same effect? Scientists from a biotechnology company called Amgen Inc. have found a naturally occurring protein within both monkeys and rats that have brought about significant changes in obesity in both animals. These protein provided healthy weight loss and rapid improvements on measures of their metabolism and heart health.

In mice who received a bioengineered version of their GDF15 protein, researchers observed that these mice would opt out of the extra-rich condensed milk, that they normally go crazy about, for their standard mouse food. After 35 days, these mice who were bioengineered lost approximately 20% of their body weight, while the placebo mice gained 6% of their starting weight. Insulin levels and total cholesterol readings were distinctly improved in the treated animals as well.

Chromosome 19 (human)

This reengineering is suggested to have the power to decrease or turn off the urge of reward-driven eating that drive many people to becoming obese, or inhibiting others from losing weight. Foods such as doughnuts, milkshakes, or bacon cheeseburgers seemed less enticing. Some of the weight-loss medications approved by the FDA similar to this reengineering appeared to nudge food preferences of obese patients into healthier directions, further leading to better health conditions. The GDF15 protein fidgets with the chemical signaling systems of humans, so scientists have been working to find equal options with similar benefits that can work together to activate many different systems that work together to increase weight loss.  



http://www.latimes.com/science/sciencenow/la-sci-sn-weight-loss-protein-20171019-story.html

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